Clinical studies have been conducted using the Re5 pulses for treatment of refractory depression. In 2010 a double blinded, placebo controlled study by Martiny et al. (2010) showed significant improvements of refractory depression after 5 weeks of treatment. Bech et al.(2011) analyzed data from that study and concluded ” Active T-PEMF was found superior to sham T-PEMF within the pharmacopsychometric triangle with a clinically significant effect size. A dose remission study was published in 2014 (Straasø et al., 2014) showing a remission rate of 73% after 8 weeks of home treatment with the Re5 medical device. A follow up study was published (Bech et al., 2015) revealing that amongst the 73 % that obtained remission in the study by Straasø et al. ( 2015), 2 years later 52 % were still in remission. Re5 gained its CE approval in September 2015.
Other clinical studies with Re5 NTS
Other clinical studies using the Re5 NTS technology are ongoing focusing on other neurological diseases.
Since the results of various clinical studies have come to public attention, scientists and doctors continuously have contacted Re5 with the request for permission to use Re5's technology and equipment to new clinical studies.
Other indications with Re5
Re5 previously obtained CE approval for the treatment of patients suffering from osteoarthritis. However, the management team of Re5-ApS decided to prioritise all its resources on the launch and commercialisation of the Re5 NTS medical device for the treatment of refractory depression.
Consequently the treatment of osteoarthritis is not being offered on the Danish market.
Martiny K., Lunde M., Bech P.
Transcranial low voltage pulsed electromagnetic fields in patients with treatment-resistant depression.
Biol. Psychiatry. 2010 Jul 15;68(2):163-9
Bech P, Gefke M, Lunde M, Lauritzen L, Martiny K. The Pharmacopsychometric
Triangle to Illustrate the Effectiveness of T-PEMF Concomitant with Antidepressants in Treatment Resistant Patients:
A Double-Blind, Randomised, Sham-Controlled Trial Revisited with Focus on the Patient-Reported Outcomes.
Depress Res Treat. 2011;2011:806298.
Straasø, B, Lauritzen, L, Lunde, M, Vinberg, M, Lindberg, L, Roj Larsen, E, Dissing, S, Bech, P.
Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression:
a randomized, double blind controlled study.
Acta Neuropsychiatrica 2014.
Bech, P, Lindberg, L, Straasø, B, Roj Larsen, E.
2-year follow-up study of patients participating in our transcranial pulsating electromagnetic fields
(T-PEMF) augmentation in treatment-resistant depression.
Acta Neuropsychiatrica 2015.