FAQ

Below are frequently asked questions and answers about the Re5 NTS equipment and the treatment of refractory depression.

This information may answer some of your questions regarding Re5 NTS. If you have any further questions, please don’t hesitate to contact us at Alexander.lidmejer@navamedic.com

What is Re5 NTS?

Re5 NTS is an abbreviation of "Re5-Neuro Treatment System". The Re5 NTS system consists of a pulse generator and 7 coils which are attached with Velcro tape and can be placed on the patient’s head. The coils transmit electromagnetic pulses to the brain that in turn induces enhanced brain activity.

The Re5 NTS technology is based on T-PEMF.

What does T-PEMF mean?

T-PEMF is an abbreviation of Transcranial Pulsed Electro Magnetic Fields - the process and technique for inducing electric pulses in the brain.

How does Re5 NTS work?

Patients suffering from refractory depression appear to have low expression of receptors in various cell types in the brain and to secrete fewer activating factors to the brain tissue. The consequence is reduced cellular communications between cells which is often termed “lower brain plasticity”. The electric pulses from the Re5–NTS coils mimic electric activity already present in brain tissue to help to activate nerve cells to secrete important signaling molecules related to growth and activity. Brain stimulation with such electric pulses thus leads to increased brain activity.

How is the Re5 NTS equipment used?

The seven coils are connected to a pulse generator and placed on top of the head of the patient. One treatment lasts 30 minutes and should be repeated daily for 8 weeks. The seven coils weigh approx. 1.1 kg. It is recommended to place your head in a relaxed position during treatment.

How long time does it take before a clinical response can be expected?

According to clinical trials significant improvement was demonstrated in some patients already 1 to 2 weeks after start of the treatment.

Who invented Re5 NTS?

Re5 NTS has been developed by Danish scientists from the University of Copenhagen in co-operation with psychiatrists at the University Hospital in Hillerød, Psychiatric Department at Aarhus Hospital in Risskov and the University Hospital (Rigshospitalet) in Copenhagen.

How long has the research and development of Re5 NTS been going on?

The basic and clinical research along with development and labelling/approval for Re5 NTS has been ongoing for approximately 15 years.

What indication is Re5 NTS approved for and when was it approved?

Re5 received a CE approval from the Danish Medical Products Agency in September 2015, including EFTA countries (Iceland, Norway and Lichtenstein). The approved therapeutic indication for Re5 NTS is refractory depression.

When will treatment with Re5 NTS be available for patients?

Re5 NTS will be introduced in Denmark during fourth quarter of 2016. For more information about the treatment centers please contact the hospitals mentioned below under: ’At which hospitals and psychiatric clinics will the Re5 NTS treatment be available?’

How efficacious is the treatment with Re5 NTS?

The results of the latest published clinical study conducted over 8 weeks, 30 minutes per day, showed a more than 60% remission rate. See reference 2 below.

Are there any known side effects of the Re5- NTS treatments?

During the clinical trials a few patients reported mild and transient side effects in the beginning of the treatment – for example nausea and headache.

Are there other concerns you should be aware of, i.e. contraindications, before starting a Re5 NTS treatment?

Children under the age of 16 and pregnant women. Cancer patients and previous cancer patients still under ongoing medical observation and treatment, patients with pacemaker, patients with open wounds near the head, patients suffering from epilepsy as well as patients with untreated psychotic symptoms, patients with immune diseases and patients suffering from alcohol and/or drug abuse are not recommended to receive the Re5 NTS treatment.

Re5 NTS has not been tested on the above mentioned patient groups this being the reason for not recommending the treatment. There is no indication that such electric pulses do induce cancer growth.

Is it safe to combine prescription drugs with Re5 NTS treatment?

Yes. The treatment with Re5 NTS is a treatment given in addition to the patient’s current medical treatment - a so-called augmentation therapy.

To whom and where should patients turn to if they are interested in treatment with Re5 NTS?

Patients should contact their own physician who can refer to one of the psychiatric hospitals or private psychiatric clinics who offers treatment with Re5 NTS.

At which hospitals and psychiatric clinics will the Re5 NTS treatment be available?

Initially the treatment will be available at the leading psychiatric centers in hospitals in Aalborg, Aarhus, Odense, Glostrup, Rigshospitalet and Hillerød.

If you are working within the healthcare system and would like to offer the Re5 NTS treatment for your patients please contact us at Alexander.lidmejer@navamedic.com

How many treatments with Re5 NTS are recommended?

Based on the published clinical trials the standard recommended treatment with Re5 NTS is 30 minutes daily for 8 weeks. For references see below.

How often do you need to repeat the treatment?

A follow up study demonstrated that approx. 56 % of the patients who obtained remission after the first treatment period were still symptom free two years later. For the group of patients going into relapse after their treatment improvements were again observed after receiving a new treatment of 8 weeks (see reference 4 below).

Is it possible to purchase the Re5 NTS equipment?

No, the Re5 NTS equipment and treatment can only be obtained through public hospitals or private psychiatric clinics.

Is Re5 NTS covered by patents?

Yes, Re5 NTS holds patents in Europe, USA, Australia, New Zeeland and Hong Kong.

Can I sign up for a Re5 NTS treatment now?

If you wish to start treatment with Re5 NTS, please contact your physician who can refer you to a center or a clinic which offers Re5 NTS.

Will Re5 ApS launch Re5 NTS in the Danish market?

Re5 ApS has signed a collaboration and distribution agreement with Navamedic Medtech AB in Sweden – a subsidiary of the Norwegian company Navamedic ASA.

Navamedic Medtech AB is responsible for the product launch in Denmark.

Contact person at Navamedic ApS - Denmark

Navamedic A/S - Denmark

Sales Manager:
Alexander Lidmejer
Mobile: +46 70 257 99 71
E-mail: Alexander.lidmejer@navamedic.com

Navamedic Office:
Østergade 1D
3600 Frederikssund
Phone: +45 4822 1838
E-mail: infodk@navamedic.com

Contact info to Re5 ApS

Re5 ApS
Niels Ebbesens Vej 31
1911 Frederiksberg
Phone: +45 52 600 500
E-mail: info@re5.com

1. Rahbek, UL,Tritsaris, K and Dissing, S.
Interaction of low frequency pulsed electromagnetic fields with living tissues: biochemical responses and clinical results.
Oral Biosciences and Medicine, vol. 2,1(29-40), 2005.

2. Straasø, B, Lauritzen, L, Lunde, M, Vinberg, M, Lindberg, L, Roj Larsen, E, Dissing, S, Bech, P.
Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression:
a randomized, double blind controlled study.
Acta Neuropsychiatrica 2014.

3. Martiny K., Lunde M., Bech P.
Transcranial low voltage pulsed electromagnetic fields in patients with treatment-resistant depression.
Biol. Psychiatry. 2010 Jul 15;68(2):163-9

4. Bech, P, Lindberg, L, Straasø, B, Roj Larsen, E.
2-year follow-up study of patients participating in our transcranial pulsating electromagnetic fields
(T-PEMF) augmentation in treatment-resistant depression.
Acta Neuropsychiatrica 2015.